Curcuma caesia and Curcuma amada have been used in the traditional Indian system of Medicine for the treatment of fever and pain. The present study evaluates the analgesic and antipyretic activity of different extracts obtained from Curcuma caesia and Curcuma amada rhizomes. Analgesic and antipyretic activities of the plant extracts was evaluated using chemical model of acute pain and brewer’s yeast induced hyperthermia in rats and their efficacy compared in terms of treatment. The writhing and pyrexia were observed at the doses of 250 and 500 mg/kg body weight of rats. Oral dose of ethanolic and aqueous extracts of both the plants showed pronounced inhibitory effect on acetic acid induced writhing response. Ethanolic and aqueous extracts also elicted significant reduction in brewer’s yeast induced hyperthermia in rats. Both the plants exerted analgesic and antipyretic activity whereby Curcuma amada showed better response in comparison to Curcuma caesia. The ethanolic extracts exerted higher efficacy than the aqueous extracts. Analgesic and antipyretic effect increased with an increase in dose. The observations provide support for the ethnobotanical use of both the plants.
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